Kojetin, Douglas J.: search on Z-Library

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1

Quantitative structural assessment of graded receptor agonism

Shang, Jinsai, Brust, Richard, Griffin, Patrick R., Kamenecka, Theodore M., Kojetin, Douglas J.

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

Language:

english

File:

PDF, 1.43 MB

english, 2019

2

Structural Analysis of Divalent Metals Binding to theBacillus subtilisResponse Regulator Spo0F: The Possibility forIn VitroMetalloregulation in the Initiation of Sporulation

Douglas J. Kojetin, Richele J. Thompson, Linda M. Benson, Stephen Naylor, Jenora Waterman, Keith G. Davies, Charles H. Opperman, Keith Stephenson, James A. Hoch, John Cavanagh

Journal:

Year:

2005

Language:

english

File:

PDF, 854 KB

english, 2005

3

Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies

Nwachukwu, Jerome C., Srinivasan, Sathish, Bruno, Nelson E., Nowak, Jason, Wright, Nicholas J., Minutolo, Filippo, Rangarajan, Erumbi S., Izard, Tina, Yao, Xin-Qui, Grant, Barry J., Kojetin, Douglas J

Journal:

Cell Chemical Biology

Year:

2017

Language:

english

File:

PDF, 2.92 MB

english, 2017

4

1H,13C and15N chemical shift assignments for the human Pitx2 homeodomain in complex with a 22-base hairpin DNA

Thomas Doerdelmann, Douglas J. Kojetin, Jamie M. Baird-Titus, Mark Rance

Journal:

Biomolecular NMR Assignments

Year:

2012

Language:

english

File:

PDF, 748 KB

english, 2012

5

1H,13C and15N chemical shift assignments for the human Pitx2 homeodomain and a R24H homeodomain mutant

Thomas Doerdelmann, Douglas J. Kojetin, Jamie M. Baird-Titus, Mark Rance

Journal:

Biomolecular NMR Assignments

Year:

2011

Language:

english

File:

PDF, 380 KB

english, 2011

6

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

Solt, Laura A., Wang, Yongjun, Banerjee, Subhashis, Hughes, Travis, Kojetin, Douglas J., Lundasen, Thomas, Shin, Youseung, Liu, Jin, Cameron, Michael D., Noel, Romain

Journal:

Year:

2012

Language:

english

File:

PDF, 644 KB

english, 2012

7

Structural and Motional Contributions of the Bacillus subtilis ClpC N-Domain to Adaptor Protein Interactions

Douglas J. Kojetin, Patrick D. McLaughlin, Richele J. Thompson, David Dubnau, Peter Prepiak, Mark Rance, John Cavanagh

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 2.12 MB

english, 2009

8

Identification of SR8278, a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB

Kojetin, Douglas, Wang, Yongjun, Kamenecka, Theodore M., Burris, Thomas P.

Journal:

ACS Chemical Biology

Year:

2011

Language:

english

File:

PDF, 1.07 MB

english, 2011

9

Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists

Romain Noel, Xinyi Song, Youseung Shin, Subhashis Banerjee, Douglas Kojetin, Li Lin, Claudia H. Ruiz, Michael D. Cameron, Thomas P. Burris, Theodore M. Kamenecka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 3.39 MB

english, 2012

10

Corrigendum to: Sub-classification of response regulators using the surface characteristics of their receiver domains (FEBS 27785): [FEBS Letters 554 (2003) 231–236]

Douglas J Kojetin, Richele J Thompson, John Cavanagh

Journal:

Year:

2004

Language:

english

File:

PDF, 200 KB

english, 2004

11

A Role for Rev-erbα Ligands in the Regulation of Adipogenesis

J. Kojetin, Douglas, P. Burris, Thomas

Journal:

Current Pharmaceutical Design

Year:

2011

Language:

english

File:

PDF, 569 KB

english, 2011

12

Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism

Zheng, Jie, Corzo, Cesar, Chang, Mi Ra, Shang, Jinsai, Lam, Vinh Q., Brust, Richard, Blayo, Anne-Laure, Bruning, John B., Kamenecka, Theodore M., Kojetin, Douglas J., Griffin, Patrick R.

Journal:

Year:

2018

Language:

english

File:

PDF, 2.81 MB

english, 2018

13

Structural basis of altered potency and efficacy displayed by a major in vivo metabolite of the anti-diabetic PPARγ drug pioglitazone

Mosure, Sarah, Shang, Jinsai, Eberhardt, Jerome, Brust, Richard, Zheng, Jie, Griffin, Patrick R., Forli, Stefano, Kojetin, Douglas J.

Journal:

Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 2.47 MB

2019

14

Solution Structure and Dynamics of LuxU from Vibrio harveyi, a Phosphotransferase Protein Involved in Bacterial Quorum Sensing

Dagny L. Ulrich, Douglas Kojetin, Bonnie L. Bassler, John Cavanagh, J. Patrick Loria

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 559 KB

english, 2005

15

Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes

Weikum, Emily R., de Vera, Ian Mitchelle S., Nwachukwu, Jerome C., Hudson, William H., Nettles, Kendall W., Kojetin, Douglas J., Ortlund, Eric A.

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 3.55 MB

english, 2017

16

REV-ERB and ROR nuclear receptors as drug targets

Kojetin, Douglas J., Burris, Thomas P.

Journal:

Nature Reviews Drug Discovery

Year:

2014

Language:

english

File:

PDF, 2.32 MB

english, 2014

17

Observing selected domains in multi-domain proteins via sortase-mediated ligation and NMR spectroscopy

Mary Anne Refaei, Al Combs, Douglas J. Kojetin, John Cavanagh, Carol Caperelli, Mark Rance, Jennifer Sapitro, Pearl Tsang

Journal:

Journal of Biomolecular NMR

Year:

2011

Language:

english

File:

PDF, 492 KB

english, 2011

18

A molecular switch regulating transcriptional repression and activation of PPARÎ³

Shang, Jinsai, Mosure, Sarah A., Zheng, Jie, Brust, Richard, Bass, Jared, Nichols, Ashley, Solt, Laura A., Griffin, Patrick R., Kojetin, Douglas J.

Journal:

Nature Communications

Year:

2020

File:

PDF, 2.71 MB

2020

19

Identification of SR3335 (ML-176): A Synthetic RORα Selective Inverse Agonist

Kumar, Naresh, Kojetin, Douglas J., Solt, Laura A., Kumar, K. Ganesh, Nuhant, Philippe, Duckett, Derek R., Cameron, Michael D., Butler, Andrew A., Roush, William R., Griffin, Patrick R., Burris, Thoma

Journal:

ACS Chemical Biology

Year:

2011

Language:

english

File:

PDF, 1.39 MB

english, 2011

20

Anti-proliferative actions of a synthetic REV-ERBα/β agonist in breast cancer cells

Wang, Yongjun, Kojetin, Douglas, Burris, Thomas P.

Journal:

Biochemical Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.56 MB

english, 2015

21

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers

Kojetin, Douglas J., Matta-Camacho, Edna, Hughes, Travis S., Srinivasan, Sathish, Nwachukwu, Jerome C., Cavett, Valerie, Nowak, Jason, Chalmers, Michael J., Marciano, David P., Kamenecka, Theodore M.,

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 3.27 MB

english, 2015

22

The Tat inhibitor didehydro-cortistatin A suppresses SIV replication and reactivation

Mediouni, Sonia, Kessing, Cari F., Jablonski, Joseph J., Thenin-Houssier, Suzie, Clementz, Mark, Kovach, Melia D., Mousseau, Guillaume, de Vera, Ian Mitchelle S., Li, Chuan, Kojetin, Douglas J., Evans

Journal:

The FASEB Journal

Year:

2019

Language:

english

File:

PDF, 1.84 MB

english, 2019

23

Defining a Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1

Munoz-Tello, Paola, Mosure, Sarah, Griffin, Patrick, Dharmarajan, Venkatasubramanian, de Vera, Ian, Kojetin, Douglas

Journal:

Biophysical Journal

Year:

2018

Language:

english

File:

PDF, 41 KB

english, 2018

24

Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements

Hudson, William H., Vera, Ian Mitchelle S. de, Nwachukwu, Jerome C., Weikum, Emily R., Herbst, Austin G., Yang, Qin, Bain, David L., Nettles, Kendall W., Kojetin, Douglas J., Ortlund, Eric A.

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 2.62 MB

english, 2018

25

Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space

Hudson, William H., Kossmann, Bradley R., de Vera, Ian Mitchelle S., Chuo, Shih-Wei, Weikum, Emily R., Eick, Geeta N., Thornton, Joseph W., Ivanov, Ivaylo N., Kojetin, Douglas J., Ortlund, Eric A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1.35 MB

english, 2015

26

Probing the Complex Binding Modes of the PPARγ Partial Agonist 2-chloro-N-(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio)phenyl)-4-(trifluoromethyl)benzenesulfonamide (T2384) to Orthosteric and Allosteric Sites with NMR Spectroscopy

Hughes, Travis S., Shang, Jinsai, Brust, Richard, de Vera, Ian Mitchelle S., Fuhrmann, Jakob, Ruiz, Claudia, Cameron, Michael D, Kamenecka, Theodore M., Kojetin, Douglas J.

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.49 MB

english, 2016

27

Insights into the Nature of DNA Binding of AbrB-like Transcription Factors

Daniel M. Sullivan, Benjamin G. Bobay, Douglas J. Kojetin, Richele J. Thompson, Mark Rance, Mark A. Strauch, John Cavanagh

Journal:

Year:

2008

Language:

english

File:

PDF, 1.00 MB

english, 2008

28

Ligand-binding dynamics rewire cellular signaling via estrogen receptor-α

Srinivasan, Sathish, Nwachukwu, Jerome C, Parent, Alex A, Cavett, Valerie, Nowak, Jason, Hughes, Travis S, Kojetin, Douglas J, Katzenellenbogen, John A, Nettles, Kendall W

Journal:

Nature Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.32 MB

english, 2013

29

[Methods in Enzymology] Two‐Component Signaling Systems, Part A Volume 422 || Classification of Response Regulators Based on Their Surface Properties

Kojetin, Douglas J.

Year:

2007

Language:

english

File:

PDF, 1.13 MB

english, 2007

30

Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex

Patil, Dipak N, Rangarajan, Erumbi S, Novick, Scott J, Pascal, Bruce D, Kojetin, Douglas J, Griffin, Patrick R, Izard, Tina, Martemyanov, Kirill A

Journal:

Year:

2018

Language:

english

File:

PDF, 6.01 MB

english, 2018

31

Mechanistic insight into protein modification and sulfur mobilization activities of noncanonical E1 and associated ubiquitin-like proteins of Archaea

Hepowit, Nathaniel L., de Vera, Ian Mitchelle S., Cao, Shiyun, Fu, Xian, Wu, Yifei, Uthandi, Sivakumar, Chavarria, Nikita E., Englert, Markus, Su, Dan, Sӧll, Dieter, Kojetin, Douglas J., Maupin-Furlow

Journal:

Year:

2016

Language:

english

File:

PDF, 1.32 MB

english, 2016

32

NMR assignment of the N-terminal repeat domain ofBacillus subtilisClpC

Douglas J. Kojetin, Patrick D. McLaughlin, Richele J. Thompson, Ronald A. Venters, Mark Rance, John Cavanagh

Journal:

Biomolecular NMR Assignments

Year:

2007

Language:

english

File:

PDF, 225 KB

english, 2007

33

Ligand and Receptor Dynamics Contribute to the Mechanism of Graded PPARγ Agonism

Travis S. Hughes, Michael J. Chalmers, Scott Novick, Dana S. Kuruvilla, Mi Ra Chang, Theodore M. Kamenecka, Mark Rance, Bruce A. Johnson, Thomas P. Burris, Patrick R. Griffin, Douglas J. Kojetin

Journal:

Year:

2012

Language:

english

File:

PDF, 1.73 MB

english, 2012

34

Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα

Youseung Shin, Romain Noel, Subhashis Banerjee, Douglas Kojetin, Xinyi Song, Yuanjun He, Li Lin, Michael D. Cameron, Thomas P. Burris, Theodore M. Kamenecka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 3.64 MB

english, 2012

35

Conformational Allostery in Nuclear Receptor/Coregulator Transcriptional Complexes

De Vera, Ian M.S., Kojetin, Douglas J.

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 116 KB

english, 2014

36

Alternative Splicing of a Î² 4 Subunit Proline-Rich Motif Regulates Voltage-Dependent Gating and Toxin Block of Ca v 2.1 Ca 2+ Channels

Helton, Thomas D., Kojetin, Douglas J., Cavanagh, John, Horne, William A.

Journal:

Journal of Neuroscience

Year:

2002

File:

PDF, 629 KB

2002

37

Structural and Biophysical Insights into the Ligand-Free Pitx2 Homeodomain and a Ring Dermoid of the Cornea Inducing Homeodomain Mutant

Doerdelmann, Thomas, Kojetin, Douglas J., Baird-Titus, Jamie M., Solt, Laura A., Burris, Thomas P., Rance, Mark

Journal:

Year:

2012

Language:

english

File:

PDF, 2.32 MB

english, 2012

38

Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine Phosphorylation

Fuhrmann, Jakob, Subramanian, Venkataraman, Kojetin, Douglas J., Thompson, Paul R.

Journal:

Cell Chemical Biology

Year:

2016

Language:

english

File:

PDF, 2.10 MB

english, 2016

39

Modification of the Orthosteric PPARγ Covalent Antagonist Scaffold Yields an Improved Dual-Site Allosteric Inhibitor

Brust, Richard, Lin, Hua, Fuhrmann, Jakob, Asteian, Alice, Kamenecka, Theodore M., Kojetin, Douglas J.

Journal:

ACS Chemical Biology

Year:

2017

Language:

english

File:

PDF, 1.83 MB

english, 2017

40

Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D28K

Kojetin, Douglas J, Venters, Ronald A, Kordys, David R, Thompson, Richele J, Kumar, Rajiv, Cavanagh, John

Journal:

Nature Structural and Molecular Biology

Year:

2006

Language:

english

File:

PDF, 425 KB

english, 2006

41

Conserved sequence-specific lincRNA–steroid receptor interactions drive transcriptional repression and direct cell fate

Hudson, William H., Pickard, Mark R., de Vera, Ian Mitchelle S., Kuiper, Emily G., Mourtada-Maarabouni, Mirna, Conn, Graeme L., Kojetin, Douglas J., Williams, Gwyn T., Ortlund, Eric A.

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 3.03 MB

english, 2014

42

Quantitative structural assessment of graded receptor agonism

Shang, Jinsai, Brust, Richard, Griffin, Patrick R., Kamenecka, Theodore M., Kojetin, Douglas J.

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

File:

PDF, 1.43 MB

2019

43

Sub-classification of response regulators using the surface characteristics of their receiver domains

Douglas J Kojetin, Richele J Thompson, John Cavanagh

Journal:

Year:

2003

Language:

english

File:

PDF, 280 KB

english, 2003

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